Journal: Clinical Ophthalmology (Auckland, N.Z.)

Article Title: Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy

doi: 10.2147/OPTH.S242926

Figure Lengend Snippet: Clinical features visible on multimodal imaging of the left eye of a 37-year-old male patient with aCSC. ( A ) Color fundus photograph showing small pigment clustering in the macula and a silhouette of the serous retinal detachment. The arrow indicates the scanning plane, which is depicted on the SD-OCT. ( B ) FAF image at diagnosis showing a speckled (ie, granular) hyper-autofluorescent lesion at the site of the serous neuroretinal detachment. ( C ) FA imaging revealed a single “hot spot” of leakage and a typical small detachment of the RPE above the inferior retinal arcade (arrow). ( D ) An SD-OCT scan at diagnosis revealed SRF accumulation, a thickened choroid, and subretinal debris, presumably consisting of non-phagocytized photoreceptor outer segments. ( E ) SRF resolved spontaneously within a few weeks. ( F ) The areas of hyper-fluorescence on mid-phase ICGA revealed diffuse choroidal hyperpermeability that was larger than the leakage site visible on FA. A recurrent episode 1.5 years later was treated with two subthreshold micropulse diode laser but did not result in resolution of the SRF. Eventually, half-dose photodynamic therapy resulted in resolution of the SRF ( G and H ). At the patient’s final visit 11 months later, hyper-autofluorescent and hypo-autofluorescent abnormalities were visible ( G ), and FA imaging revealed a slightly enlarged area of RPE alterations ( H ). Abbreviations: aCSC, acute central serous chorioretinopathy; ICGA, indocyanine green angiography; FA, Fluorescein angiography; FAF, Fundus autofluorescence; SD-OCT, spectral-domain optical coherence tomography; SRF, subretinal serous fluid; RPE, retinal pigment epithelium.

Article Snippet: These examinations included best-corrected visual acuity (BCVA, measured with a Snellen chart, then converted to ETDRS letters for statistical comparison); slit-lamp examination and/or color fundus photography (Topcon Corp., Tokyo, Japan or Carl Zeiss Meditec AG, Jena, Germany); spectral-domain OCT (Cirrus HD-OCT, Carl Zeiss Meditec, Jena, Germany, OCT-HS100, Canon Inc., Tokyo, Japan, or Spectralis HRA+OCT, Heidelberg Engineering, Heidelberg, Germany); fundus autofluorescence imaging (FAF) (Heidelberg Spectralis HRA+OCT or Topcon Corp.); FA (Topcon Corp., Spectralis HRA+OCT, or Carl Zeiss Meditec); and ICGA (Topcon Corp., Heidelberg Spectralis HRA+OCT, or Carl Zeiss Meditec).

Techniques: Imaging, Biomarker Discovery, Fluorescence, Tomography

Journal: Clinical Ophthalmology (Auckland, N.Z.)

Article Title: Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy

doi: 10.2147/OPTH.S242926

Figure Lengend Snippet: Clinical features visible on multimodal imaging of the right eye of a 37-year-old female patient ( A – D ) and a 34-year-old male patient ( E – H ) with aCSC. ( A and E ) FA revealed one focal “hot spot” of leakage and no changes in the retinal pigment epithelium. ( B and F ) Despite these circumscribed lesions on FA, ICGA revealed a more widespread area of hyper-fluorescence, which corresponded with multifocal ( B ) or monofocal ( F ) choroidal leakage. ( C and G ) FAF imaging revealed speckled (ie, granular) hyper-autofluorescent changes at the site of serous neuroretinal detachment in both patients, which corresponded with serous retinal detachment visualized on OCT ( D, H ). Abbreviations: aCSC, acute central serous chorioretinopathy; ICGA, indocyanine green angiography; FA, Fluorescein angiography; FAF, Fundus autofluorescence; OCT, optical coherence tomography; SRF, subretinal serous fluid; RPE, retinal pigment epithelium.

Article Snippet: These examinations included best-corrected visual acuity (BCVA, measured with a Snellen chart, then converted to ETDRS letters for statistical comparison); slit-lamp examination and/or color fundus photography (Topcon Corp., Tokyo, Japan or Carl Zeiss Meditec AG, Jena, Germany); spectral-domain OCT (Cirrus HD-OCT, Carl Zeiss Meditec, Jena, Germany, OCT-HS100, Canon Inc., Tokyo, Japan, or Spectralis HRA+OCT, Heidelberg Engineering, Heidelberg, Germany); fundus autofluorescence imaging (FAF) (Heidelberg Spectralis HRA+OCT or Topcon Corp.); FA (Topcon Corp., Spectralis HRA+OCT, or Carl Zeiss Meditec); and ICGA (Topcon Corp., Heidelberg Spectralis HRA+OCT, or Carl Zeiss Meditec).

Techniques: Imaging, Fluorescence, Tomography

Journal: Molecular Genetics & Genomic Medicine

Article Title: Novel homozygous CLN3 missense variant in isolated retinal dystrophy: A case report and electron microscopic findings

doi: 10.1002/mgg3.1308

Figure Lengend Snippet: Multimodal retinal images and full‐field electroretinograms during the patient's clinical course. Fundus photographs (a), late‐phase fluorescein angiography images (b), and electroretinograms (c) taken at 26 years of age. Ultrawide‐field fundus photographs (d) and fundus autofluorescence images (e) taken at 38 years of age. Optical coherence tomography (f) shows disruption of all outer retinal layers at the center of the maculae. Left column: images of the right eye, right column: images of the left eye in (a), (b), (d)–(f)

Article Snippet: We performed a comprehensive ophthalmic examination, including decimal best corrected visual acuity (BCVA), slit‐lamp examination, funduscopy, fluorescein angiography, and fundus autofluorescence imaging (FAF) using an Optos 200Tx, Ultra‐Wide Field Retinal Imaging System (Optos), and spectral‐domain Cirrus optical coherence tomography (OCT; Carl Zeiss Meditec AG).

Techniques: Tomography, Disruption